Eptinezumabas gali padėti gydyti lėtinę migreną

Eptinezumabas gali padėti gydyti lėtinę migreną

2017 metų pradžioje vykusiame kasmečiame Amerikos neurologijos akademijos susitikime pristatytas pranešimas apie eksperimentinį vaistą eptinezumabą. Mokslininkai pateikė įrodymų, kad viena minėto preparato infuzija 4–8 savaitėms reikšmingai sumažina lėtinės migrenos požymius bei pagerina kasdienį pacientų gyvenimą.

Mokslininkų komanda iš Alberto Einšteino medicinos universiteto Niujorke (Jungtinės Amerikos Valstijose) neseniai atliktoje IIb stadijos studijoje analizavo eptinezumabo infuzijų efektyvumą gydant lėtinę migreną. Migrenos simptomų kaita buvo vertinama pasitelkiant galvos skausmo vertinimo testą ir apskaičiuojant, kiek procentų per 12 stebėjimo savaičių sumažėjo pacientus varginantys simptomai (≥75 proc., ≥50 proc., ≥25 proc., ≤25 proc.) po vienos intraveninės eptinezumabo infuzijos (300 mg, 100 mg, 30 mg arba 10 mg) arba vienos placebo infuzijos.

Eptinezumabas, dar vadinamas ALD403, yra eksperimentinis monokloninis antikūnas.

Į tyrimą iš viso buvo įtrukti 588 suaugusieji, atsitiktine tvarka suskirstyti į eptinezumabo arba placebo grupes. Visus tiriamuosius daugiau nei 15 dienų per mėnesį vargino galvos skausmas (per šį laikotarpį fiksuotos daugiau nei 5 migrenos atakos ir daugiau nei 8 dienos, kuriomis pacientai patyrė migrenos priepuolius). Galvos skausmo intensyvumo kitimas specialiais klausimynais vertintas kelis kartus.

Tyrimo rezultatai atskleidė, kad, paskyrus 300 mg eptinezumabo infuziją, ≥75 proc. skausmas sumažėjo 33 proc. pacientų, ≥50 proc. – 57 proc. pacientų. Po 100 mg eptinezumabo infuzijoa ≥75 proc. skausmo intensyvumo sumažėjimą nurodė 31 proc. pacientų, ≥50 proc. – 55 proc. pacientų. Placebo grupėje šie skaičiai buvo atitinkamai 21 proc. ir 41 proc. Abi eptinezumabo dozės buvo gerai toleruojamos.

Mokslininkai teigia, kad šio tyrimo rezultatai yra daug žadantys. Tikėtina, kad netolimoje ateityje rinkoje pasirodys dar vienas efektyvus vaistas migrenai gydyti.

Parengta pagal http://www.medicalnewstoday.com/articles/317340.php


146 mintys apie “Eptinezumabas gali padėti gydyti lėtinę migreną

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  140. Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.

  141. This is getting a bit more subjective, but I much prefer the Zune Marketplace. The interface is colorful, has more flair, and some cool features like ‘Mixview’ that let you quickly see related albums, songs, or other users related to what you’re listening to. Clicking on one of those will center on that item, and another set of „neighbors“ will come into view, allowing you to navigate around exploring by similar artists, songs, or users. Speaking of users, the Zune „Social“ is also great fun, letting you find others with shared tastes and becoming friends with them. You then can listen to a playlist created based on an amalgamation of what all your friends are listening to, which is also enjoyable. Those concerned with privacy will be relieved to know you can prevent the public from seeing your personal listening habits if you so choose.

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